Which of the following is true about the B and O Railroad?

The statement that the B and O Railroad reached Wheeling in 1853 is significant because it marks an important milestone in the development of rail transportation in West Virginia and the broader region. The Baltimore and Ohio Railroad, established in the early 19th century, was instrumental in connecting the Eastern United States with the West. By reaching Wheeling, the railroad helped facilitate trade and transportation of goods, particularly essential resources like coal, timber, and other agricultural products.

This development played a vital role in the economic growth of West Virginia, as it allowed for easier access to markets and contributed to the industrialization of the area. When the B and O Railroad established its route to Wheeling, it not only enhanced transportation efficiency but also laid the groundwork for future expansion of rail networks in West Virginia and beyond.

The other statements do not accurately represent the history and significance of the B and O Railroad in the same way. For example, while the B and O was one of the oldest railroads, it was not the first railroad in the United States. It also didn't exclusively transport coal; instead, it handled a variety of freight. Finally, while it did establish routes to the Midwest, that was not its primary focus at the outset of its operations.