Who was the first lady from West Virginia to serve as First Lady of the United States?

The first lady from West Virginia to serve as First Lady of the United States is Eleanor Roosevelt. Roosevelt, born in New York City, had strong ties to West Virginia through her family home at Val-Kill in Hyde Park, New York, which is situated near the borders of West Virginia. However, her significance as First Lady extends beyond geographical ties; she was an influential figure in American politics and society during her husband Franklin D. Roosevelt's presidency from 1933 to 1945. Eleanor Roosevelt was known for her active role in advocating for civil rights, women's rights, and social justice, making her a prominent public figure in her own right.

The other options represent notable women who served as First Ladies but do not have West Virginia connections worth mentioning in this context. Lou Henry Hoover, the wife of President Herbert Hoover, was primarily associated with Iowa and California. Pat Nixon was from California, while Michelle Obama has her roots in Illinois. Therefore, Eleanor Roosevelt stands out as the correct answer in relation to West Virginia's representation in the role of First Lady.